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fibroblast growth factor 10; FGF-10; keratinocyte growth factor 2 (FGF10)
Function:
- role in the regulation of embryonic development, cell proliferation & cell differentiation
- required for normal branching morphogenesis
- may play a role in wound healing
- interacts with FGFR1 & FGFR2
- interacts with FGFBP1
Structure:
- belongs to the heparin-binding growth factors family
Compartment: secreted (putative)
Pathology:
- defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal & salivary glands
- defects in FGF10 are a cause of Levy-Hollister syndrome
General
fibroblast growth factor
glycoprotein
Properties
SIZE: entity length = 208 aa
MW = 23 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-37}
N-glycosylation site {N51}
serine-rich region {52-62}
MOTIF: serine residue (SEVERAL)
N-glycosylation site {N196}
SECRETED-BY: endothelial cell
Database Correlations
OMIM correlations
MORBIDMAP 602115
UniProt O15520
Pfam PF00167
Entrez Gene 2255
Kegg hsa:2255
References
- UniProt :accession O15520
- NIEHS-SNPs
http://egp.gs.washington.edu/data/fgf10/