Fez family zinc finger protein 2 (forebrain embryonic zinc finger-like protein 2, zinc finger protein Fez-like, zinc finger protein 312, FEZF2, FEZL, ZNF312, FKSG36)

Function: 1) transcription repressor 2) required for specification of corticospinal motor neurons & other subcerebral projection neurons 3) may play a role in layer & neuronal subtype-specific patterning of subcortical projections & axonal fasciculation 4) controls development of dendritic arborization & spines of large layer V pyramidal neurons 5) may be involved in innate immunity Compartment: nucleus Alternative splicing: named isoforms=2 Structure: - belongs to the krueppel C2H2-type zinc-finger protein family - contains 6 C2H2-type zinc fingers

General

C2H2 type zinc finger protein transcriptional silencer (transcriptional repressor)

Properties

SIZE: MW = 49 kD entity length = 459 aa COMPARTMENT: cell nucleus MOTIF: Engrailed homology 1 repressor {27-42} glycine-rich region {102-125} Zn finger C2H2-type SITE: 277-299 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 305-327 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 333-355 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 361-383 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 389-411 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 417-440 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 607414 UniProt Q8TBJ5 Pfam PF00096 Entrez Gene 94016

References

UniProt :accession Q8TBJ5