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Fez family zinc finger protein 1 (zinc finger protein 312B, FEZF1, FEZ, ZNF312B)
Function:
- transcription repressor
- role in axonal projection proper termination of olfactory sensory neurons
- role in rostro-caudal patterning of diencephalon & in prethalamic formation
- regulates layer formation in olfactory bulb development and the interneuron
- may be required for correct rostral migration of interneuron progenitors in olfactory bulb
Structure:
- belongs to the krueppel C2H2-type zinc-finger protein family
- contains 6 C2H2-type zinc fingers
Compartment: nucleus
Alternative splicing: named isoforms=3
General
C2H2 type zinc finger protein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: MW = 52 kD
entity length = 475 aa
COMPARTMENT: cell nucleus
MOTIF: Engrailed homology 1 repressor {28-43}
Zn finger C2H2-type
SITE: 260-282
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 288-310
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 316-338
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 344-366
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 372-394
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 400-423
EFFECTOR-BOUND: Zn+2
proline-rich region
SITE: 433-468
MOTIF: proline residue (SEVERAL)
Database Correlations
UniProt A0PJY2
Pfam PF00096
References
UniProt :accession A0PJY2