Search
feverfew
Uses:
1) migraine headache: abortive & prophylactic therapy
2) fever
3) menstrual problems
4) stomach ache
Contraindications:
1) pregnancy
2) lactation
3) thrombocytopenia
Dosage:
- 50-125 mg of dried leaf/day in divided doses
- discontinue 7 days prior to surgery [3]
Adverse effects:
1) appears to be safe for up to 4 months (no long-term studies)
2) withdrawal may cause an increase in the frequency & severity of headache
3) chewing* feverfew leaves can cause:
a) mouth ulcers
b) tongue & oral mucosa inflammation
c) swelling of the lips
d) loss of taste
4) allergy
5) platelet inhibition, bleeding [3]
6) GI upset [3]
* feverfew in capsule may avoid these adverse effects
Drug interactions:
- anticoagulants
- antiplatelet agents including NSAIDs
Mechanism of action:
1) multiple active constituents, including parthenolide
2) may inhibit platelet aggregation & serotonin release from platelets & leukocytes
3) may inhibit serum proteases
4) may inhibit formation of leukotrienes
5) may inhibit phospholipase & prostaglandin synthesis
General
pharmaceutical herb; medicinal herb; herbal supplement; botanical
References
- Kaiser Permanente, Northern California, Pharmacy update
- Prescriber's Letter 12(4): 2005
Supplements for Migraine
Detail-Document#: 210414
(subscription needed) http://www.prescribersletter.com
- Geriatrics at your Fingertips, 13th edition, 2011
Reuben DB et al (eds)
American Geriatric Society
Component-of
Migrelief