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FERM, RhoGEF & pleckstrin domain-containing protein 2 (FERM domain including RhoGEF, FIR, FARP2, KIAA0793)
Function:
1) Rho-guanine nucleotide exchange factor
2) activates RAC1
3) role in response to class 3 semaphorins & remodeling of actin cytoskeleton
4) interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity
5) dissociates from PLXNA1 when SEMA3A binds to receptor
6) interacts with PIP5K1C via its FERM domain
7) interaction with PIP5K1C enhanced byvSEMA3A binding
Alternative splicing: named isoforms=2
Structure:
- contains 1 DH domain (DBL-homology domain)
- contains 1 FERM domain
- contains 2 PH domains
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: MW = 120 kD
entity length = 1054 aa
MOTIF: FERM domain
NAME: FERM domain
SITE: 44-324
serine-rich region {425-428}
MOTIF: serine residue (SEVERAL)
proline-rich region
SITE: 453-511
MOTIF: proline residue (SEVERAL)
Dbl homology domain {535-726}
PH domain {755-852}
PH domain {929-1026}
Database Correlations
UniProt O94887
PFAM correlations
References
UniProt :accession O94887