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FERM, RhoGEF and pleckstrin domain-containing protein 1 (chondrocyte-derived ezrin-like protein, FARP1, CDEP)
Function:
- Rho-guanine nucleotide exchange factor (putative)
Structure:
- contains 1 DH domain (DBL-homology domain)
- contains 1 FERM domain
- contains 2 PH domains
Alternative splicing: named isoforms=2
Expression:
- detected in cAMP-treated chondrocytes, but not in untreated chondrocytes
- detected in fetal brain, heart & spleen, & in adult testis, kidney & lung
- up-regulated in response to cAMP in cultured embryonic chondrocytes
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: MW = 119 kD
entity length = 1045 aa
MOTIF: FERM domain
NAME: FERM domain
SITE: 40-320
glutamate-rich region {449-453}
MOTIF: glutamate residue (SEVERAL)
Dbl homology domain {540-730}
PH domain {759-856}
PH domain {932-1029}
Database Correlations
OMIM 602654
UniProt Q9Y4F1
PFAM correlations
References
UniProt :accession Q9Y4F1