fer3-like protein (nephew of atonal 3, basic helix-loop-helix protein N-twist, neuronal twist, FERD3L, NATO3, NTWIST)

Function: - transcription factor - binds to the E-box - functions as inhibitor of transcription - DNA binding requires dimerization with an E protein - inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins (putative) - heterodimer with TCF3/E12 - interacts with the bHLH domain of TCF3/E12 (putative) Structure: contains 1 basic helix-loop-helix (bHLH) domain Compartment: nucleus (putative)

General

basic helix loop helix (bHLH) family transcription factor transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 166 aa MW = 19 kD COMPARTMENT: cell nucleus MOTIF: glutamate-rich region {63-68} MOTIF: glutamate residue (SEVERAL) glutamate-rich region {75-81} MOTIF: glutamate residue (SEVERAL) helix-loop-helix NAME: helix-loop-helix SITE: 93-154 FOR-BINDING-VIA: helix-loop-helix

Database Correlations

UniProt Q96RJ6 Pfam PF00010 Kegg hsa:2228

References

UniProt :accession Q96RJ6