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fenfluramine/phentermine (fen-phen)

fenfluramine/phentermine Taken off the market (1999) because of markedly increased risk of valvular heart disease & myocardial infarction. Reference [2] & [3] suggest that the risk of valvular heart disease may have been initially overestimated.

General

pharmacologic combination

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Journal Watch vol 19 #22, pg 177, Nov 15, 1999
  3. Burger et al J Am Coll Cardiol 34:1153, 1999

Components

fenfluramine (Pondimin, Ponderil, Ponderex, Adipomin, Fintepla) phentermine (Fastin, Ionamin, Adipex)