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Fc receptor-like protein 6 (FcR-like protein 6, FcRL6, Fc receptor homolog 6, FcRH6, IFGP6, FCRL6, FCRH6)
Function:
- interacts with PTPN11
- phosphorylated on Tyr, inducing association with PTPN11
Structure:
- contains 3 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 ITIM motif, phosphorylated ITIM motif has role in PTPN11 binding
Compartment: membrane
Alternative splicing: named isoforms=4
Expression:
- expressed by cytolytic cells including NK cells, effector & effector-memory CD8+ T-cells
Pathology:
- expression among T-cells is greatly expanded in HIV-1 infected individuals, & includes not only effector & effector-memory CD8+ T-cells but also populations of CD4+ T-cells
General
glycoprotein
immunoglobulin superfamily protein
membrane protein
phosphoprotein
Properties
SIZE: MW = 48 kD
entity length = 434 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
immunoglobulin superfamily domain {20-95}
MOTIF: cysteine residue {C39}
MODIFICATION: cysteine residue {C83}
N-glycosylation site {N65}
cysteine residue {C83}
MODIFICATION: cysteine residue {C39}
immunoglobulin superfamily domain {111-197}
MOTIF: cysteine residue {C132}
MODIFICATION: cysteine residue {C180}
cysteine residue {C180}
MODIFICATION: cysteine residue {C132}
immunoglobulin superfamily domain {207-293}
MOTIF: cysteine residue {C228}
MODIFICATION: cysteine residue {C276}
N-glycosylation site {N273}
cysteine residue {C276}
MODIFICATION: cysteine residue {C228}
transmembrane domain {308-328}
immunoreceptor tyrosine-based inhibitory motif (ITIM) {369-374}
MOTIF: Tyr phosphorylation site {Y371}
Database Correlations
UniProt Q6DN72
Pfam PF00047
References
UniProt :accession Q6DN72