Fc receptor-like protein 5 (immunoglobulin receptor translocation-associated gene 2 protein, BXMAS1, CD307 antigen, FCRL5, FCRH5, IRTA2, UNQ503/PRO820)

Function: 1) role in B-cell development & differentiation in peripheral lymphoid organs 2) immunoregulatory role in marginal zone B-cells (putative) Structure: - contains 2 copies of cytoplasmic motif immunoreceptor tyrosine-based inhibitor motif (ITIM) - contains 8 Ig-like C2-type domaina (immunoglobulin-like) Compartment: membrane Alternative splicing: named isoforms=5 Expression: - expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes & in the intraepithelial & interfollicular regions of the tonsil. - isoforms 1, 3, 4 & 5 are expressed in lymph node, spleen, bone marrow, 7 small intestine with preponderance of isoform 3 Pathology: - expressed in many lymphoma cell lines - expressed on hairy cell leukemia cells - chromosomal duplication dup(1)(q21q32) involving FCRL5 is found in Burkitt lymphoma cell lines with 1q21 abnormalities Laboratory: - may be useful markers of B-cell stages

General

glycoprotein immunoglobulin superfamily protein membrane protein

Properties

SIZE: MW = 106 kD entity length = 977 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-15} immunoglobulin superfamily domain {23-101} MOTIF: cysteine residue {C44} MODIFICATION: cysteine residue {C85} cysteine residue {C85} MODIFICATION: cysteine residue {C44} immunoglobulin superfamily domain {188-271} MOTIF: cysteine residue {C211} MODIFICATION: cysteine residue {C260} cysteine residue {C260} MODIFICATION: cysteine residue {C211} immunoglobulin superfamily domain {287-374} MOTIF: cysteine residue {C308} MODIFICATION: cysteine residue {C355} cysteine residue {C355} MODIFICATION: cysteine residue {C308} immunoglobulin superfamily domain {380-463} MOTIF: N-glycosylation site {N383} cysteine residue {C401} MODIFICATION: cysteine residue {C448} cysteine residue {C448} MODIFICATION: cysteine residue {C401} immunoglobulin superfamily domain {473-556} MOTIF: cysteine residue {C494} MODIFICATION: cysteine residue {C541} cysteine residue {C541} MODIFICATION: cysteine residue {C494} immunoglobulin superfamily domain {566-651} MOTIF: cysteine residue {C587} MODIFICATION: cysteine residue {C634} cysteine residue {C634} MODIFICATION: cysteine residue {C587} immunoglobulin superfamily domain {659-744} MOTIF: cysteine residue {C680} MODIFICATION: cysteine residue {C727} cysteine residue {C727} MODIFICATION: cysteine residue {C680} immunoglobulin superfamily domain {752-834} MOTIF: cysteine residue {C773} MODIFICATION: cysteine residue {C819} cysteine residue {C819} MODIFICATION: cysteine residue {C773} transmembrane domain {852-872} immunoreceptor tyrosine-based inhibitory motif (ITIM) {922-927} immunoreceptor tyrosine-based inhibitory motif (ITIM) {952-957}

Database Correlations

OMIM correlations UniProt Q96RD9 Pfam PF00047

References

UniProt :accession Q96RD9