Fc receptor-like protein 4 (FcR-like protein 4, FcRL4, Fc receptor homolog 4, FcRH4, IFGP family protein 2, hIFGP2, immune receptor translocation-associated protein 1, FCRL4, FCRH4, IFGP2, IRTA1)

Function: - may function as an inhibitor of B cell receptor signaling - may function in the B cell-mediated immune response - phosphorylated on cytoplasmic tyrosines upon activation Structure: contains 4 Ig-like C2-type domain (immunoglobulin-like) Compartment: cell membrane Alternative splicing: named isoforms=2 Expression: - specifically expressed by memory & monocytoid B cells which populate spleen & lymph nodes - preferentially expressed in memory B cells associated with mucosal tissue (at protein level) Pathology: 1) chromosomal translocation t(1;1)(p36.3;q21.1-2) involving FCRL4 is found in non-Hodgkin lymphoma 2) chromosomal translocation t(1;14)(q21;q32) involving FCRL4 is found in multiple myeloma. translocation forms a FCRL4-IGHA1 fusion protein

General

Fc receptor glycoprotein phosphoprotein

Properties

SIZE: entity length = 515 aa MW = 57 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-19} MOTIF: peptide motif {17-18} immunoglobulin superfamily domain {23-97} MOTIF: cysteine residue {C44} MODIFICATION: cysteine residue {C85} cysteine residue {C85} MODIFICATION: cysteine residue {C44} immunoglobulin superfamily domain {102-183} MOTIF: cysteine residue {C123} MODIFICATION: cysteine residue {C167} cysteine residue {C167} MODIFICATION: cysteine residue {C123} immunoglobulin superfamily domain {193-271} MOTIF: cysteine residue {C212} MODIFICATION: cysteine residue {C261} cysteine residue {C261} MODIFICATION: cysteine residue {C212} immunoglobulin superfamily domain {275-374} MOTIF: cysteine residue {C310} MODIFICATION: cysteine residue {C359} cysteine residue {C359} MODIFICATION: cysteine residue {C310} N-glycosylation site {N374} transmembrane domain {388-408} immunoreceptor tyrosine-based inhibitory motif (ITIM) {449-454} immunoreceptor tyrosine-based inhibitory motif (ITIM) {461-466} immunoreceptor tyrosine-based inhibitory motif (ITIM) {491-496}

Database Correlations

OMIM 605876 UniProt Q96PJ5 Pfam PF00047 Kegg hsa:8341

References

UniProt :accession Q96PJ5