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Fc receptor-like protein 2; FcR-like protein 2; FcRL2; Fc receptor homolog 2; FcRH2; IFGP family protein 4; immunoglobulin receptor translocation-associated protein 4; SH2 domain-containing phosphatase anchor protein 1; CD307b (FCRL2, FCRH2, IFGP4, IRTA4, SPAP1, UNQ9236/PRO31998)
Function:
1) regulatory role in normal & neoplastic B cell development
2) tyrosine-phosphorylated isoform 2 interacts with PTPN6
Structure:
- type 1 membrane protein
- contains 2-4 ITIM motifs
- phosphorylated ITIM motif binds SH2 domain of PTPN6
- contains 4 Ig-like C2-type domains
- isoform 2 is N-glycosylated & O-glycosylated
Compartment:
- cell membrane; single-pass type 1 membrane protein
Alternative splicing: named isoforms=5
Expression:
- expressed in the secondary lymphoid organs, spleen, lymph node
- expression limited to mature B cells, CD19 +
Related
Fc receptor-like B (Fc receptor-like protein 2, Fc receptor-like & mucin-like protein 2, Fc receptor-related protein Y, FcRY, Fc receptor homolog expressed in B cells protein 2, FREB-2, FCRLB, FCRL2, FCRLM2, FCRY, FREB2)
PAPA syndrome; pyogenic sterile arthritis, pyoderma gangrenosum, & acne; familial recurrent arthritis
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
cell surface receptor
glycoprotein
immunoglobulin superfamily protein
Properties
SIZE: entity length = 508 aa
MW = 56 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
immunoglobulin superfamily domain {20-98}
immunoglobulin superfamily domain {109-187}
MOTIF: cysteine residue {C128}
MODIFICATION: cysteine residue {C177}
cysteine residue {C177}
MODIFICATION: cysteine residue {C128}
immunoglobulin superfamily domain {201-290}
MOTIF: N-glycosylation site {N204}
cysteine residue {C226}
MODIFICATION: cysteine residue {C275}
N-glycosylation site {N234}
cysteine residue {C275}
MODIFICATION: cysteine residue {C226}
immunoglobulin superfamily domain {300-387}
MOTIF: cysteine residue {C321}
MODIFICATION: cysteine residue {C368}
N-glycosylation site {N343}
N-glycosylation site {N355}
N-glycosylation site {N365}
cysteine residue {C368}
MODIFICATION: cysteine residue {C321}
transmembrane domain {402-422}
immunoreceptor tyrosine-based inhibitory motif (ITIM) {446-451}
immunoreceptor tyrosine-based inhibitory motif (ITIM) {460-465}
immunoreceptor tyrosine-based inhibitory motif (ITIM) {472-477}
immunoreceptor tyrosine-based inhibitory motif (ITIM) {500-505}
Database Correlations
OMIM 606509
UniProt Q96LA5
Entrez Gene 79368
Kegg hsa:79368
References
UniProt :accession Q96LA5