Fc receptor-like protein 1 (FcR-like protein 1, FcRL1, Fc receptor homolog 1, FcRH1, IFGP family protein 1, hIFGP1, immune receptor translocation-associated protein 5, FCRL1, FCRH1, IFGP1, IRTA5)

Function: - may function as an activating coreceptor in B cells - may function in B cells activation & differentiation - phosphorylated on tyrosines upon activation Structure: contains 3 Ig-like C2-type domain (immunoglobulin-like) Compartment: cell membrane Alternative splicing: named isoforms=4 Expression: - primarily expressed in secondary lymphoid tissues by mature subsets of B cells - detected in spleen, lymph node, heart, skeletal muscle, kidney, liver & placenta - specifically expressed by mature B lineage cells with higher expression in naive versus memory B cells (at protein level) - down-regulated in activated B cells

General

Fc receptor glycoprotein membrane protein

Properties

SIZE: entity length = 429 aa MW = 47 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-16} immunoglobulin superfamily domain {17-104} MOTIF: cysteine residue {C38} MODIFICATION: cysteine residue {C86} cysteine residue {C86} MODIFICATION: cysteine residue {C38} immunoglobulin superfamily domain {109-200} MOTIF: cysteine residue {C134} MODIFICATION: cysteine residue {C183} cysteine residue {C183} MODIFICATION: cysteine residue {C134} immunoglobulin superfamily domain {208-291} MOTIF: cysteine residue {C229} MODIFICATION: cysteine residue {C276} cysteine residue {C276} MODIFICATION: cysteine residue {C229} N-glycosylation site {N293} transmembrane domain {308-328} immunoreceptor tyrosine-based inhibitory motif (ITIM) {354-359} immunoreceptor tyrosine-based inhibitory motif (ITIM) {367-372} immunoreceptor tyrosine-based inhibitory motif (ITIM) {379-384} immunoreceptor tyrosine-based inhibitory motif (ITIM) {410-415} immunoreceptor tyrosine-based inhibitory motif (ITIM) {423-428}

Database Correlations

OMIM 606508 UniProt Q96LA6 Pfam PF00047 Kegg hsa:1153

References

UniProt :accession Q96LA6