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Fc receptor-like B (Fc receptor-like protein 2, Fc receptor-like & mucin-like protein 2, Fc receptor-related protein Y, FcRY, Fc receptor homolog expressed in B cells protein 2, FREB-2, FCRLB, FCRL2, FCRLM2, FCRY, FREB2)
Structure:
- contains 2 Ig-like C2-type domains (immunoglobulin-like)
Compartment:
- cytoplasm, endoplasmic reticulum
- seems not to be secreted
Alternative splicing:
- named isoforms=5
- additional isoforms seem to exist
Expression:
- expressed at low levels
- expressed in B-lymphocytes
- detected in tonsil, lung, kidney, spleen & placenta
- expressed by a small subset of germinal center B cells in tonsils & by melanocytes (at protein level)
Related
Fc receptor-like protein 2; FcR-like protein 2; FcRL2; Fc receptor homolog 2; FcRH2; IFGP family protein 4; immunoglobulin receptor translocation-associated protein 4; SH2 domain-containing phosphatase anchor protein 1; CD307b (FCRL2, FCRH2, IFGP4, IRTA4, SPAP1, UNQ9236/PRO31998)
General
glycoprotein
Properties
SIZE: entity length = 426 aa
MW = 47 kD
COMPARTMENT: cytoplasm
endoplasmic reticulum
MOTIF: signal sequence {1-17}
immunoglobulin superfamily domain {23-101}
MOTIF: cysteine residue {C44}
MODIFICATION: cysteine residue {C85}
cysteine residue {C85}
MODIFICATION: cysteine residue {C44}
immunoglobulin superfamily domain {103-189}
MOTIF: cysteine residue {C124}
MODIFICATION: cysteine residue {C168}
N-glycosylation site {N152}
cysteine residue {C168}
MODIFICATION: cysteine residue {C124}
Database Correlations
UniProt Q6BAA4
Kegg hsa:1279
References
UniProt :accession Q6BAA4