Fc receptor-like & mucin-like 1 (Fc receptor-like A, Fc receptor homolog expressed in B-cells, Fc receptor-related protein X, FcRX, Fc receptor-like protein, FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB, UNQ291/PRO329)

Function: - role in B-cell differentiation & lymphomagenesis (putative) Structure: - monomer or homodimer, disulfide-linked - contains 2 Ig-like C2-type domains (immunoglobulin-like) Compartment: secreted, cytoplasm Alternative splicing: named isoforms=8 Expression: - expressed specifically in primary & secondary lymphoid tissues, including lymph node, spleen & tonsil - specifically expressed in B-cells - also expressed in melanoma & melanocytes

General

immunoglobulin superfamily protein secreted protein

Properties

SIZE: MW = 39 kD entity length = 359 aa COMPARTMENT: cytoplasm MOTIF: signal sequence {1-27} immunoglobulin superfamily domain {70-159} MOTIF: cysteine residue {C99} MODIFICATION: cysteine residue {C143} cysteine residue {C143} MODIFICATION: cysteine residue {C99} immunoglobulin superfamily domain {170-257} MOTIF: cysteine residue {C192} MODIFICATION: cysteine residue {C240} cysteine residue {C240} MODIFICATION: cysteine residue {C192} proline-rich region SITE: 269-315 MOTIF: proline residue (SEVERAL)

Database Correlations

OMIM 606891 UniProt Q7L513 Pfam PF00047

References

UniProt :accession Q7L513