CD32; low affinity immunoglobulin gamma Fc region receptor II-c; IgG Fc receptor II-c; Fc-gamma RII-c; Fc-gamma-RIIc; FcRII-c; CDw32 (FCGR2C, FCG2, IGFR2)

Function: - receptor for the Fc region of complexed IgG, low affinity receptor - role in effector & regulatory functions including: a) phagocytosis of immune complexes b) modulation of antibody production by B-cells Structure: - contains 2 ITAM motifs - contains 2 Ig-like C2-type domain (immunoglobulin-like) Compartment: - isoforms IIC1 IIC2, IIC3: cell membrane - isoform IIC4: cytoplasm (probable) Alternative splicing: named isoforms=4 Expression: - isoform IIC1 is detected in monocytes, macrophages, neutrophils & natural killer cells

General

CD32 or Fc gamma [IgG] receptor-II (low affinity) glycoprotein phosphoprotein

Properties

SIZE: entity length = 323 aa MW = 36 kD COMPARTMENT: cytoplasm cellular membrane MOTIF: signal sequence {1-42} immunoglobulin superfamily domain {48-127} MOTIF: cysteine residue {C71} MODIFICATION: cysteine residue {C113} N-glycosylation site {N106} cysteine residue {C113} MODIFICATION: cysteine residue {C71} immunoglobulin superfamily domain {131-213} MOTIF: cysteine residue {C152} MODIFICATION: cysteine residue {C196} N-glycosylation site {N180} N-glycosylation site {N187} cysteine residue {C196} MODIFICATION: cysteine residue {C152} transmembrane domain {224-246} Tyr phosphorylation site {Y310}

Database Correlations

UniProt P31995 Pfam PF00047 Kegg hsa:9103

References

UniProt :accession P31995