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CD32; low affinity immunoglobulin gamma Fc region receptor II-a; IgG Fc receptor II-a; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CDw32 (FCGR2A, FCG2, FCGR2A1, IGFR2)
Function:
- binds to the Fc region of IgG, low affinity receptor
- by binding to IgG, initiates cellular responses against pathogens & soluble antigens
- interacts with INPP5D/SHIP1 & INPPL1/SHIP2, regulating its function
- associates with/activates c-src protein [2]
Structure: contains 2 Ig-like C2-type domain (immunoglobulin-like)
Compartment: cell membrane
Expression:
- found on monocytes, neutrophils & eosinophil platelets
General
CD32 or Fc gamma [IgG] receptor-II (low affinity)
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 317 aa
MW = 35 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-33}
immunoglobulin superfamily domain {39-118}
MOTIF: cysteine residue {C62}
MODIFICATION: cysteine residue {C104}
N-glycosylation site {N97}
cysteine residue {C104}
MODIFICATION: cysteine residue {C62}
immunoglobulin superfamily domain {122-204}
MOTIF: cysteine residue {C143}
MODIFICATION: cysteine residue {C187}
N-glycosylation site {N178}
cysteine residue {C187}
MODIFICATION: cysteine residue {C143}
transmembrane domain {218-240}
Tyr phosphorylation site {Y288}
Database Correlations
OMIM 146790
UniProt P12318
Pfam PF00047
References
- Stockinger H et al
Molecular characterization and functional analysis of the
leukocyte surface protein CD31.
J Immunol. 1990 Dec 1;145(11):3889-97.
PMID: 1700999
- Bolen JB, Rowley RB, Spana C, Tsygankov AY.
The Src family of tyrosine protein kinases in hemopoietic
signal transduction.
FASEB J. 1992 Dec;6(15):3403-9. Review.
PMID: 1281458
- UniProt :accession P12318