fatty acyl-CoA reductase 2 (male sterility domain- containing protein 1, MLSTD1, FAR2)

Function: - catalyzes reduction of fatty acyl-CoA to fatty alcohols - preferred substrates are C16, C18, C18:1 & C18:2 but low activity can be observed with C10-C14 substrates Fatty acyl-CoA + 2 NADPH = fatty alcohol + 2 NADP⁺ Structure: belongs to the fatty acyl-CoA reductase family Compartment: - peroxisome membrane - endoplasmic reticulum membrane - peroxisome in cells expressing low levels of the protein - peroxisome & endoplasmic reticulum in cells expressing high levels of the protein

General

membrane protein oxidoreductase

Properties

SIZE: MW = 59 kD entity length = 515 aa COMPARTMENT: endoplasmic reticulum MOTIF: transmembrane domain {465-484} transmembrane domain {491-510}

Database Correlations

UniProt Q96K12 PFAM correlations

References

UniProt :accession Q96K12