fatty acid synthetase complex

Function: - fatty acid biosynthesis - chain termination & release of free fatty acids via hydrolysis of thioester - chain length of the released fatty acid is usually C16* Structure: - subunits: - fatty acid synthetase (FASN) - S-acyl fatty acid synthase thioesterase, medium chain (OLAH)

Properties

SUBUNITS: S-acyl fatty acid synthase thioesterase, medium chain MOTIF: serine residue {S101} histidine residue {H237} fatty acid synthase COMPARTMENT: cytoplasm MOTIF: Beta-ketoacyl synthase {1-414} acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl cysteine residue {C161} Ser phosphorylation site {S207} Acyl and malonyl transferases {429-817} MOTIF: serine residue {S581} histidine residue {H878} Enoyl reductase {1635-1863} MOTIF: cofactor-binding site [1671-1688] COFACTOR-BOUND: NADP Beta-ketoacyl reductase {1864-2118} MOTIF: cofactor-binding site [1886-1901] COFACTOR-BOUND: NADP Acyl carrier {2123-2179} Ser phosphorylation site {S2198} Thr phosphorylation site {T2204} Thioesterase {2207-2511} MOTIF: Ser phosphorylation site {S2236} serine residue {S2308} histidine residue {H2481}

References

UniProt :accession Q9NZI8, Q9BZF9

Components

fatty acid synthase; includes: [acyl-carrier-protein] S-acetyltransferase; [acyl-carrier-protein] S-malonyltransferase; 3-oxoacyl-[acyl-carrier-protein] synthase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase; enoyl-[acyl-carrier-protein] reductase; Oleoyl-[acyl-carrier-protein] hydrolase (FASN, FAS) S-acyl fatty acid synthase thioesterase, medium chain (oleoyl-ACP hydrolase, thioesterase 2, thioesterase domain-containing protein 1, OLAH, THEDC1)