fatty-acid amide hydrolase 2 (oleamide hydrolase 2, anandamide amidohydrolase 2, amidase domain-containing protein, FAAH2, AMDD)

Function: - degrades bioactive fatty acid amides to their corresponding acids thus terminate their signaling functions, including: - oleamide - endogenous cannabinoid, anandamide - myristic amide - hydrolyzes monounsaturated substrate anandamide preferentially compared to polyunsaturated substrates - inhibited by O-aryl carbamates Structure: - homodimer - belongs to the amidase family Compartment: membrane Expression: - expressed in brain, small intestine, testis > heart, kidney, liver, lung, prostate

General

hydrolase membrane protein

Properties

SIZE: MW = 58 kD entity length = 532 aa COMPARTMENT: cellular membrane MOTIF: transmembrane domain {11-31} lysine residue {K131} serine residue {S206} serine residue {S230}

Database Correlations

UniProt Q6GMR7 Pfam PF01425

References

UniProt :accession Q6GMR7