fatty acid 2-hydroxylase (fatty acid alpha-hydroxylase, FA2H, FAAH)

Function: - required for alpha-hydroxylation of free fatty acids & the formation of alpha-hydroxylated sphingolipids - role in myelination in the CNS & PNS, & for epidermal permeability barrier homeostasis Cofactor: iron (putative) Structure: - histidine box domains may contain the active site &/or be involved in metal ion binding - contains 1 cytochrome b5 heme-binding domain Compartment: endoplasmic reticulum membrane Expression: - detected in differentiating cultured keratinocytes (at protein level) - detected in epidermis & cultured keratinocytes - highly expressed in brain & colon detected at lower levels in testis, prostate, pancreas & kidney - up-regulated during keratinocyte differentiation

General

enzyme membrane protein

Properties

SIZE: entity length = 372 aa MW = 43 kD COMPARTMENT: endoplasmic reticulum MOTIF: heme-binding site [8-86] MOTIF: Iron [Fe]-binding site SITE: 43-43 Iron [Fe]-binding site SITE: 69-69 transmembrane domain {168-188} transmembrane domain {213-233} transmembrane domain {268-288} transmembrane domain {290-310}

Database Correlations

UniProt Q7L5A8 PFAM correlations

References

UniProt :accession Q7L5A8