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fasL gene

The gene for FasL. This is the murine gld gene. A genetic deficiency in gld or lpr (murine Fas-antigen gene) causes a lymphoproliferation & autoimmune disease that resembles Lupus [2].

Related

Fas ligand; tumor necrosis factor ligand superfamily member 6; Fas antigen ligand; CD95L protein; apoptosis antigen ligand; APTL; CD178 (FASLG, APT1LG1, FASL, TNFSF6)

General

unclassified gene

Properties

TEMPLATE-FOR: messenger RNA TEMPLATE-FOR: Fas ligand LOCUS: human chromosome-1 Q23 MOTIF: transcription factor binding site FOR-BINDING-OF: interferon regulatory factor 1 EkB site SP1-binding site FOR-BINDING-OF: transcription factor Sp1 transcriptional start site exon (4) intron (3) transcriptional termination site

Database Correlations

OMIM 134638

References

  1. Takahashi et al Intenational Immunology 6:1567 1994
  2. Orrenius J Internal Med 237:529 1995