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Fas ligand; tumor necrosis factor ligand superfamily member 6; Fas antigen ligand; CD95L protein; apoptosis antigen ligand; APTL; CD178 (FASLG, APT1LG1, FASL, TNFSF6)
Function:
- cytokine that binds to FAS (CD95, TNFRSF6), a receptor that transduces the apoptotic signal into cells
- may be involved in cytotoxic T-cell mediated apoptosis & in T-cell development
- FasL-mediated cytotoxicity & perforin-mediated target cell lysis appear to be the 2 major effector pathways in T-cell cytotoxicity [3]
- FasL-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both
- binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects
- the soluble form derives from the membrane form by proteolytic processing
Structure:
- homotrimer (probable)
- N-glycosylated
- belongs to the tumor necrosis factor family
Compartment:
- cell membrane, secreted
- may be released into the extracellular fluid, probably by cleavage from the cell surface
Alternative splicing: named isoforms=2
Expression:
- expressed on the surface of activated T cells & in testis
Pathology:
- defects in FASL are the cause of autoimmune lymphoproliferative syndrome type 1B
Related
fasL gene
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
oligomerizing protein
plasma membrane protein
tumor necrosis factor (TNF) family protein
Properties
SIZE: entity length = 281 aa
MW = 31 kD
COMPARTMENT: plasma membrane
MOTIF: proline-rich region
SITE: 4-70
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 45-65
MOTIF: proline residue (SEVERAL)
transmembrane domain {81-102}
peptide motif {129-130}
N-glycosylation site {N184}
cysteine residue {C202}
MODIFICATION: cysteine residue {C233}
cysteine residue {C233}
MODIFICATION: cysteine residue {C202}
N-glycosylation site {N250}
N-glycosylation site {N260}
References
- Cory S.
Apoptosis. Fascinating death factor.
Nature. 1994 Jan 27;367(6461):317-8.
PMID: 7509455
- Nagata S, Golstein P.
The Fas death factor.
Science. 1995 Mar 10;267(5203):1449-56. Review.
PMID: 7533326
- Lacronique V, Mignon A, Fabre M, Viollet B, Rouquet N,
Molina T, Porteu A, Henrion A, Bouscary D, Varlet P,
Joulin V, Kahn A.
Bcl-2 protects from lethal hepatic apoptosis induced by an
anti-Fas antibody in mice.
Nat Med. 1996 Jan;2(1):80-6.
PMID: 8564847
- Entrez Gene :accession 356
- UniProt :accession P48023
- FASLGbase; Note: FASLG mutation db
http://bioinf.uta.fi/FASLGbase/
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=FASLG
- Wikipedia; Note: FAS-ligand entry
http://en.wikipedia.org/wiki/FAS_ligand
Databases & Figures
OMIM correlations
UniProt P48023
Pfam PF00229
Entrez Gene 356
KEGG correlations
signaling pathways: caspases