fas/Apo-1 gene (CD95 gene, murine lpr gene)

The fas/Apo-1/CD95 gene is the murine lpr gene. A genetic deficiency in lpr or gld (murine FasL gene) causes a lymphoproliferation & autoimmune disease that resembles Lupus However, humans with Lupus do not have mutations in the fas gene. The fas/apo1 gene contains 3 transcriptional initiation sites, a GC-rich element (CpG island), & consensus sequences for binding of AP1, GF-1, NY-Y, CP-2, EBP20 & c-myb, but lacks canonical TATA & CCAAT boxes.

Related

CD95; Fas antigen; tumor necrosis factor receptor superfamily member 6; apo-1 antigen; apoptosis-mediating surface antigen FAS; FASLG receptor (FAS, APT1, FAS1, TNFRSF6) fasL gene

Properties

TEMPLATE-FOR: messenger RNA TEMPLATE-FOR: Fas antigen SIZE: entity length = 26 KB entity length = 9 EXONS MOTIF: CpG island c-myb site AP1 site NAME: AP1 site transcriptional start site exon (9) intron (8) transcriptional termination site