FAS-associated factor 1 (Protein FAF1, hFAF1, FAF1)

Function: - potentiates but cannot initiate FAS-induced apoptosis - specifically interacts with cytoplasmic domain of FAS Structure: contains 1 UBX domain Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - expressed in testis > skeletal muscle, heart > prostate, thymus, ovary, small intestine, colon - not detected in peripheral blood leukocytes

General

nuclear protein phosphoprotein

Properties

SIZE: MW = 74 kD entity length = 650 aa COMPARTMENT: cell nucleus MOTIF: Tyr phosphorylation site {Y225} UBX {569-646}

Database Correlations

OMIM 604460 UniProt Q9UNN5 Pfam PF00789

References

UniProt :accession Q9UNN5