Fascin-2; retinal fascin (FSCN2)

Function: - acts as an actin bundling protein - may play a pivotal role in photoreceptor cell-specific events, including as disk morphogenesis Structure: belongs to the fascin family Expression: - localized specifically in the outer & inner segments of the photoreceptor cells in the retina Pathology: - defects in FSCN2 are the cause of retinitis pigmentosa type 30

General

cytoskeletal protein phosphoprotein

Properties

SIZE: entity length = 492 aa MW = 55 kD COMPARTMENT: cytoplasm MOTIF: phosphorylation site binding site FOR-BINDING-OF: F-actin

Database Correlations

OMIM correlations UniProt O14926 Pfam PF06268 Entrez Gene 25794 Kegg hsa:25794

References

UniProt :accession O14926