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far upstream element-binding protein 1; FBP; FUSE-binding protein 1; DNA helicase V; hDH V (FUBP1)
Function:
- regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter
- may act as transcriptional activator & transcriptional silencer
- ubiquitinated, targeting it for proteasome-mediated degradation
- found in a complex with PUF60 & far upstream element (FUSE) DNA segment
- interacts with PUF60 & JTV1
Structure: contains 4 KH domains
Compartment: nucleus (probable)
Alternative splicing: named isoforms=2
General
Far upstream element binding protein (FUSE binding protein)
Properties
SIZE: entity length = 644 aa
MW = 68 kD
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
glycine-rich region {13-26}
Ser phosphorylation site {S52}
Ser phosphorylation site {S55}
Tyr phosphorylation site {Y58}
KH domain
SITE: 100-164
FOR-BINDING-OF: ribonucleic acid
MOTIF: Ser phosphorylation site {S140}
Thr phosphorylation site {T153}
KH domain
SITE: 185-251
FOR-BINDING-OF: ribonucleic acid
KH domain
SITE: 275-339
FOR-BINDING-OF: ribonucleic acid
glycine-rich region {349-396}
KH domain
SITE: 376-443
FOR-BINDING-OF: ribonucleic acid
proline-rich region
SITE: 450-560
MOTIF: proline residue (SEVERAL)
Tyr phosphorylation site {Y626}
Ser phosphorylation site {S630}
Database Correlations
OMIM 603444
UniProt Q96AE4
PFAM correlations
Entrez Gene 8880
Kegg hsa:8880
References
UniProt :accession Q96AE4