farnesyl pyrophosphate synthase; FPP synthase; FPS; (2E,6E)-farnesyl diphosphate synthase; dimethylallyltranstransferase; farnesyl diphosphate synthase; geranyltranstransferase (FDPS, FPS, KIAA1293)

Function: - enzyme of isoprenoid & cholesterol biosynthesis - catalyzes formation of farnesyl pyrophosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, & ubiquinones - also serves as substrate for protein farnesylation & geranylgeranylation - catalyzes sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, & then with the resultant geranylpyrophosphate to form farnesyl pyrophosphate - isoprenoid biosynthesis; - farnesyl pyrophosphate biosynthesis; - farnesyl pyrophosphate from geranyl pyrophosphate & isopentenyl pyrophosphate: step 1/1 - geranyl pyrophosphate biosynthesis - geranyl pyrophosphate from dimethylallyl pyrophosphate & isopentenyl pyrophosphate: step 1/1 - interacts with RSAD2 - interacts with HTLV-1 protein p13(II) dimethylallyl pyrophosphate + isopentenyl pyrophosphate = pyrophosphate + geranyl pyrophosphate geranyl pyrophosphate + isopentenyl pyrophosphate = pyrophosphate + (2E,6E)-farnesyl pyrophosphate Cofactor: binds 3 Mg⁺² per subunit Structure: - homodimer - belongs to the FPP/GGPP synthase family Compartment: cytoplasm Pathology: - inactivated by interferon-induced RSAD2 - this inactivation may result of disruption of lipid rafts at the plasma membrane, & thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell Note: - uncertain whether Met-1 or Met-67 is the initiator

Related

farnesyl pyrophosphate synthase; FPP synthase; FPS; (2E,6E)-farnesyl diphosphate synthase; dimethylallyltranstransferase; farnesyl diphosphate synthase; geranyltranstransferase (FDPS, FPS, KIAA1293) farnesylpyrophosphate synthase gene

General

dimethylallyltransferase oligomerizing protein prenyltransferase

Properties

SUBUNITS: prenyl transferase-alpha MOTIF: proline-rich region SITE: 22-31 MOTIF: proline residue (SEVERAL) PFTA {112-146} PFTA {147-180} PFTA {181-215} PFTA {216-249} PFTA {255-289} prenyl transferase-beta MOTIF: binding site FOR-BINDING-OF: ras superfamily protein SIZE: entity length = 419 aa MW = 48 kD COMPARTMENT: cytoplasm MOTIF: binding site SITE: 123-123 FOR-BINDING-OF: isopentenyl pyrophosphate binding site SITE: 126-126 FOR-BINDING-OF: isopentenyl pyrophosphate binding site SITE: 162-162 FOR-BINDING-OF: isopentenyl pyrophosphate phenylalanine residue {164} phenylalanine residue {165} Mg+2-binding site SITE: 169-169 Mg+2-binding site SITE: 173-173 binding site SITE: 178-178 FOR-BINDING-OF: dimethylallyl pyrophosphate binding site SITE: 179-179 FOR-BINDING-OF: isopentenyl pyrophosphate active site acidic region MOTIF: acidic residue (SEVERAL) binding site SITE: 266-266 FOR-BINDING-OF: dimethylallyl pyrophosphate binding site SITE: 267-267 FOR-BINDING-OF: dimethylallyl pyrophosphate binding site SITE: 306-306 FOR-BINDING-OF: dimethylallyl pyrophosphate Mg+2-binding site SITE: 309-309 binding site SITE: 323-323 FOR-BINDING-OF: dimethylallyl pyrophosphate binding site SITE: 332-332 FOR-BINDING-OF: dimethylallyl pyrophosphate

Database Correlations

OMIM 134629 UniProt P14324 Pfam PF00348 Entrez Gene 2224 Kegg hsa:2224 ENZYME correlations

References

UniProt :accession P14324

Components

CAAX farnesyltransferase alpha subunit (FNTA, RAS proteins prenyltransferase-alpha) prenyltransferase-beta