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Fanconi anemia complementation group complex (FA complex)
Function:
- complex formed by Fanconi anemia complementation group proteins
- DNA repair protein
- postreplication repair
- cell cycle checkpoint function
- interstrand DNA cross-link repair
- maintenance of normal chromosome stability
- hematopoiesis
- interacts with FANCD2
- see Fanconi anemia
Structure:
- subunits: PHF9, FANCA, FANCC, FANCE, FANCF, FANCG, FANCM
Pathology:
- complex in not found in patients with Fanconi anemia
Related
Fanconi anemia
Fanconi anemia group D2 protein; protein FACD2 (FANCD2, FACD)
General
molecular complex
nuclear protein
Properties
COMPARTMENT: cell nucleus
SUBUNITS: E3 ubiquitin-protein ligase FANCL
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: RING-finger {307-365}
EFFECTOR-BOUND: Zn+2
FOR-BINDING-OF: DNA motif
Fanconi anemia group A protein
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: nuclear translocation signal {18-34}
Ser phosphorylation site {S849}
Ser phosphorylation site {S850}
Ser phosphorylation site {S858}
Ser phosphorylation site {S1449}
Fanconi anemia group B protein
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T839}
Fanconi anemia group C protein
COMPARTMENT: cytoplasm
cell nucleus
Fanconi anemia group E protein
COMPARTMENT: cell nucleus
MOTIF: FANCC interaction {150-371}
MOTIF: Ser phosphorylation site {S249}
Fanconi anemia group F protein
COMPARTMENT: cell nucleus
Fanconi anemia group G protein
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: tetratricopeptide repeat {246-279}
tetratricopeptide repeat {344-377}
tetratricopeptide repeat {453-486}
tetratricopeptide repeat {514-547}
Fanconi anemia group M protein
COMPARTMENT: cell nucleus
MOTIF: helicase
NAME: helicase
SITE: 98-266
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 111-118
DEAD/H box
NAME: DEAD/H box
SITE: 214-217
Helicase C-terminal {452-627}
Ser phosphorylation site {S1437}
FAAP24/EME1 interaction {1727-2048}
References
- UniProt :accession O75529
- UniProt :accession Q9HB96
Components
E3 ubiquitin-protein ligase FANCL; Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kD; FAAP43 (FANCL, PHF9)
Fanconi anemia group A protein; protein FACA (FANCA FAA FACA FANCH)
Fanconi anemia group B protein; protein FACB; Fanconi anemia-associated polypeptide of 95 kDa; FAAP95 (FANCB)
Fanconi anemia group C protein; protein FACC (FANCC, FAC, FACC)
Fanconi anemia group E protein; protein FANCE (FANCE)
Fanconi anemia group F protein; protein FACF (FANCF)
Fanconi anemia group G protein; protein FACG; DNA repair protein XRCC9 (FANCG, XRCC9)
Fanconi anemia group M protein; protein FACM; ATP-dependent RNA helicase FANCM; Fanconi anemia-associated polypeptide of 250 kDa; FAAP250; protein Hef ortholog (FANCM, KIAA1596)