Fanconi anemia-associated protein of 24 kD (FAAP24, C19orf40)

Function: - role in DNA repair through recruitment of FA core complex to damaged DNA - regulates FANCD2 monoubiquitylation upon DNA damage - induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed - targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA - belongs to the multisubunit FA complex - interacts with FANCM Structure: - C-terminal region is distantly related to RuvA domain 2, a DNA-binding domain Compartment: nucleus

Properties

SIZE: MW = 24 kD entity length = 215 aa COMPARTMENT: cell nucleus MOTIF: RuvA domain 2-like {160-215}

References

UniProt :accession Q9BTP7