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familial platelet disorder with associated myeloid malignancy
Pathology:
- qualitative & quantitative platelet defects
- propensity to develop acute myelogenous leukemia
Genetics:
- autosomal dominant
- associated with defects in RUNX1
Laboratory:
- CBC may show thrombocytopenia
- platelet aggregation may be abnormal
Complications:
- propensity to develop acute myelogenous leukemia
General
genetic disease of the blood/bone marrow
Database Correlations
OMIM 601399
References
OMIM :accession 601399