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familial obesity
Genetic disorders with obesity as an isolated or predominant feature
Genetics:
1) autosomal recessive
a) leptin deficiency
b) leptin receptor deficiency
c) prohormone convertase-1 deficiency
d) proopiomelanocortin deficiency
2) autosomal dominant
a) mutation in the melanocortin-4 receptor gene
b) defects in AGRP
3) X-linked
- genetic variations in SLC6A14 may be associated with susceptibility to X-linked obesity
4) major obesity susceptibility loci appear to be located on
a) chromosome 4
b) chromosome 10
c) chromosome 20
5) single-nucleotide polymorphisms
a) ghrelin gene
b) APOE
c) TGF-beta-1
6) a polymorphism of mitochondrial DNA has been associated with obesity-related variables & lipid metabolism
General
lipid metabolism, inborn error; lipid storage disease; lipidosis
Database Correlations
OMIM correlations
MORBIDMAP correlations
References
OMIM :accession 601665