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familial breast-ovarian cancer
familial predisposition to breast cancer & ovarian cancer
Genetics:
- susceptibility associated with defects in RAD51D (type 4)
Clinical manifestations:
- early age of onset of breast cancer (often before age 50)
- increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently)
- frequent occurrence of breast cancer among men
- increased incidence of prostate cancer in men
Related
breast cancer
ovarian cancer
General
hereditary neoplastic syndrome; cancer susceptibility syndrome
Database Correlations
OMIM 614291
References
OMIM :accession 614291