coagulation factor XIa

Function: - serine protease, proteolytically activates factor XII & prekallikrein - factor XIa triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX - selective cleavage of Arg-|-Ala & Arg-|-Val bonds in factor IX to form factor IXa

Related

coagulation cascade coagulation factor XI; FXI; plasma thromboplastin antecedent; PTA; contains: coagulation factor XIa heavy chain; coagulation factor XIa light chain (F11)

General

coagulation factor serine protease trypsin family

Properties

COMPARTMENT: plasma STATE: active state MOTIF: charge relay system MOTIF: aspartate residue histidine residue serine residue allosteric site FOR-BINDING-OF: complement C1 inhibitor