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coagulation factor Va or accelerin
Function:
- cofactor for the prothrombinase activity of factor Xa that results in activation of prothrombin to thrombin
- thrombin activates factor V proteolytically to the active cofactor, factor Va
Structure:
- subunits factor Va heavy chain factor Va light chain, non-covalently bound
- interaction between the two chains is Ca+2-dependent
Interactions
molecular events
Related
coagulation cascade
coagulation factor V; activated protein C cofactor; proaccelerin, labile factor; contains: coagulation factor V heavy chain; coagulation factor V light chain (F5)
Coagulation factor VI (factor Va) Ag in tissue
General
coagulation factor
multisubunit protein
protease; proteinase; endopeptidase
Properties
COMPARTMENT: plasma
STATE: active state
MOTIF: active site
SUBUNITS: factor Va heavy chain
MOTIF: Ca+2-binding site
EFFECTOR-BOUND: Ca+2
acidic region
MOTIF: acidic residue (SEVERAL)
factor Va light chain
MOTIF: Ca+2-binding site
EFFECTOR-BOUND: Ca+2
binding site
FOR-BINDING-OF: phospholipid
References
- Textbook of Biochemistry with Clinical Correlations,
3rd ed., TM Devlin (ed), Wiley-Liss, NY 1992 pg 969
- UniProt :accession P12259
Component-of
macromolecular complex
Components
factor Va heavy chain
factor Va light chain