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coagulation factor IXa
Function:
- vitamin K-dependent serine protease
- proteolytically activates factor X to form factor Xa
- selective cleavage of Arg-|-Ile bond in factor X to form factor Xa
Pharmacology:
- Available under the name BeneFix (Baxter and American home Products)
- Used to treat hemophilia B
Interactions
molecular events
Related
coagulation cascade
coagulation factor IX; Christmas factor; plasma thromboplastin component; PTC; contains: coagulation factor IXa light chain; coagulation factor IXa heavy chain (F9)
General
coagulation factor
serine protease trypsin family
Properties
COMPARTMENT: plasma
STATE: active state
MOTIF: charge relay system
MOTIF: aspartate residue
histidine residue
serine residue
allosteric site
FOR-BINDING-OF: coagulation factor VIIIa
Component-of
macromolecular complex