factor in the germline alpha (transcription factor FIGa, FIGalpha, FIGLA)

Function: 1) germ-line specific transcription factor 2) role in postnatal oocyte-specific gene expression 3) role in the expression of multiple oocyte-specific genes, including: those that initiate folliculogenesis those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization & early embryonic survival 4) essential for oocyte survival & formation of primordial follicles 5) persistence of FIGLAin adult females suggests that it may regulate additional pathways essential for normal ovarian development 6) binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters 7) forms a heterodimer with TCF3/isoform E12 Structure: - contains 1 basic helix-loop-helix (bHLH) domain Compartment: nucleus Expression: - expressed in germ cells, fetal ovary, ovarian follicles, mature oocytes, & less frequently in preimplantation embryo

General

DNA-binding protein transcription factor (TF)

Properties

SIZE: MW = 24 kD entity length = 219 aa COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 66-77 helix-loop-helix NAME: helix-loop-helix SITE: 78-118 FOR-BINDING-VIA: helix-loop-helix

Database Correlations

OMIM 608697 UniProt Q6QHK4 Pfam PF00010

References

UniProt :accession Q6QHK4