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F1F0 ATPase (respiratory complex 5, ATP synthase)
Function:
- mitochondrial membrane F1F0 ATPase produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain
Structure:
- F-type ATPases consist of two structural domains F1-ATPase - containing the extramembraneous catalytic core & F0 - containing the membrane proton channel, linked together by a central stalk & a peripheral stalk
- during catalysis, ATP synthesis in the catalytic domain of F1-ATPase is coupled via a rotary mechanism of the central stalk subunits to proton translocation via F0
Interactions
molecular events
Related
electron transport
General
electrogenic H+ ATPase or proton pump
electron transport enzyme
F-type ATPase
molecular complex
Properties
COMPARTMENT: inner mitochondrial membrane
mitochondrial matrix
STATE: active state
SUBUNITS: coupling factor 0 (F0, CF0)
F1 ATPase
Database Correlations
Kegg map/map00193
ENZYME 3.6.1.34
References
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 597
- UniProt :accession P00846
- Wikipedia, ATP synthase
http://www.en.wikipedia.org/wiki/ATP_synthase
Components
coupling factor 0 (F0, CF0)
coupling factor 1 or F1 ATPase