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extracellular sulfatase Sulf-2 (HSulf-2, SULF2, KIAA1247, UNQ559/PRO1120)
Function:
- sulfatase, has arylsulfatase activity
- highly specific endoglucosamine-6-sulfatase activity
- can remove sulfate from C-6 position of glucosamine within specific subregions of intact heparin.
- binds 1 Ca+2 per subunit
Kinetic parameters:
- Optimum pH is 7.0-8.0
Structure: belongs to the sulfatase family
Compartment: endoplasmic reticulum, Golgi, cell surface
Alternative splicing: named isoforms=2
Expression:
- expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney, placenta
General
Ca+2 binding protein
glycoprotein
sulfatase
Properties
SIZE: MW = 100 kD
entity length = 870 aa
COMPARTMENT: golgi
endoplasmic reticulum
MOTIF: signal sequence {1-24}
Ca+2-binding site
SITE: 52-52
Ca+2-binding site
SITE: 53-53
N-glycosylation site {N65}
Ca+2-binding site
SITE: 88-88
N-glycosylation site {N112}
N-glycosylation site {N132}
N-glycosylation site {N149}
N-glycosylation site {N171}
N-glycosylation site {N198}
N-glycosylation site {N241}
Ca+2-binding site
SITE: 317-317
Ca+2-binding site
SITE: 318-318
N-glycosylation site {N561}
N-glycosylation site {N608}
N-glycosylation site {N717}
N-glycosylation site {N754}
N-glycosylation site {N764}
Database Correlations
UniProt Q8IWU5
Pfam PF00884
References
UniProt :accession Q8IWU5