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exostosin-like 3; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; tumor suppressor protein EXTL3; multiple exostosis-like protein 3; Hereditary multiple exostoses gene isolog; EXT-related protein 1 (EXTL3, EXTL1L, EXTR1, KIAA0519)
Function:
- probable glycosyltransferase
- glycan metabolism; heparan sulfate biosynthesis
Structure:
- belongs to the glycosyltransferase 47 family
Compartment:
- endoplasmic reticulum membrane
- single-pass type 2 membrane protein
Expression: ubiquitous
Note: uncertain whether Met-1, Met-6 or Met-20 is the initiator
Related
exostosin
General
anti-oncoprotein (tumor suppressor protein)
glycoprotein
glycosyltransferase
membrane protein
Properties
SIZE: entity length = 919 aa
MW = 105 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {31-51}
N-glycosylation site {N277}
N-glycosylation site {N290}
N-glycosylation site {N592}
manganese [Mn]-binding site
SITE: 746-746
N-glycosylation site {N790}
cysteine residue {C831}
MODIFICATION: cysteine residue {C879}
cysteine residue {C879}
MODIFICATION: cysteine residue {C831}
Database Correlations
OMIM 605744
UniProt O43909
PFAM correlations
Entrez Gene 2137
Kegg hsa:2137
ENZYME 2.4.1.223
References
- UniProt :accession O43909
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/
- Functional glycomics gateway - GTase, Note: exostosin-like 3
http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewglycoEnzyme.jsp?gbpId=gt_hum_531