Search
exostosin-like 2; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; alpha-1,4-N-acetylhexosaminyltransferase EXTL2; alpha-galNAcT EXTL2; EXT-related protein 2; contains: processed exostosin-like 2 (EXTL2, EXTR2)
Function:
- glycosyltransferase
- required for biosynthesis of heparan-sulfate
- responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) & alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains
- glycan metabolism; heparan sulfate biosynthesis
- the soluble form derives from the membrane form by proteolytic processing
Structure:
- belongs to the glycosyltransferase 47 family
Compartment:
- endoplasmic reticulum membrane
- single-pass type 2 membrane protein (putative)
- processed exostosin-like 2: secreted
- a soluble form is found in serum/plasma
Expression: ubiquitous
Related
exostosin
General
anti-oncoprotein (tumor suppressor protein)
glycoprotein
glycosyltransferase
membrane protein
Properties
SIZE: entity length = 330 aa
MW = 37 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {23-43}
proteolytic site {53-54}
N-glycosylation site {N74}
manganese [Mn]-binding site
SITE: 152-152
cysteine residue {C243}
MODIFICATION: cysteine residue {C296}
cysteine residue {C296}
MODIFICATION: cysteine residue {C243}
Database Correlations
OMIM 602411
UniProt Q9UBQ6
Pfam PF09258
Entrez Gene 2135
Kegg hsa:2135
ENZYME 2.4.1.223
References
- UniProt :accession Q9UBQ6
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/
- Functional glycomics gateway - GTase, Note: exostosin-like 2
http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewglycoEnzyme.jsp?gbpId=gt_hum_530