exosome multienzyme ribonuclease complex

Function: 1) 3'->5' exoribonuclease 2) degrades inherently unstable mRNAs containing AU-rich elements within their 3' untranslated regions Structure: - consists of at least 11 subunits: - EXOSC1/CSL4, EXOSC2/RRP4, EXOSC3/RRP40, EXOSC4/RRP41, EXOSC5/RRP46, EXOSC6/MTR3, EXOSC7/RRP42, EXOSC8/RRP43, EXOSC9/Scl-75, DIS3/RRP44, EXOSC10/Scl-100 (only in nuclear complex)

Related

exosome (RNase complex) (GO:0000178) exosome; ectosome; oncosome

General

exoribonuclease molecular complex

Properties

COMPARTMENT: cell nucleus MOTIF: active site SUBUNITS: exosome component 1 exosome component 2 MOTIF: Thr phosphorylation site {T32} Thr phosphorylation site {T37} Thr phosphorylation site {T45} Tyr phosphorylation site {Y46} S1 domain {79-159} exosome component 3 exosome component 4 exosome component 5 MOTIF: Ser phosphorylation site {S20} Ser phosphorylation site {S27} exosome component 7 exosome component 8 exosome complex exonuclease RRP44 MOTIF: PINc {64-182} exosome complex exonuclease RRP45 MOTIF: Ser phosphorylation site {S392} Ser phosphorylation site {S394} exosome complex exonuclease MTR3 MOTIF: active site exosome component 10 MISC-INFO: EC-3.1.13.-

References

UniProt :accession Q9Y3B2, Q06265

Components

exosome complex exonuclease MTR3 (mRNA transport regulator 3 homolog, hMtr3, exosome component 6, p11, EXOSC6 MTR3) exosome complex exonuclease RRP44 (ribosomal RNA processing protein 44, DIS3 protein homolog, DIS3, KIAA1008, RRP44) exosome complex exonuclease RRP45 (polymyositis/scleroderma autoantigen 1, autoantigen PM/Scl 1, polymyositis/scleroderma autoantigen 75 kD, PM/Scl-75, P75 polymyositis-scleroderma overlap syndrome associated autoantigen, EXOSC9, PMSCL1) exosome component 10; polymyositis/scleroderma autoantigen 2; polymyositis/scleroderma autoantigen 100 kD; PM/Scl-100; P100 polymyositis-scleroderma overlap syndrome associated autoantigen (EXOSC10, PMSCL2) exosome component 1; 3'-5' exoribonuclease CSL4 homolog; CGI-108 (EXOSC1, CSL4) exosome component 2 (exosome complex exonuclease RRP4, ribosomal RNA processing protein 4, EXOSC2) exosome component 3; exosome complex exonuclease RRP40; ribosomal RNA processing protein 40; p10; CGI-102 (EXOSC3) exosome component 4 (exosome complex exonuclease RRP41, ribosomal RNA processing protein 41, p21A, ski6, EXOSC4) exosome component 5; exosome complex exonuclease RRP46; ribosomal RNA processing protein 46; p21B (EXOSC5) exosome component 7 (exosome complex exonuclease RRP42, ribosomal RNA processing protein 42, p8, EXOSC7, KIAA0116) exosome component 8 (exosome complex exonuclease RRP43, ribosomal RNA processing protein 43, p9, Opa-interacting protein 2, OIP2, EXOSC8)