exosome component 5; exosome complex exonuclease RRP46; ribosomal RNA processing protein 46; p21B (EXOSC5)

Function: - component of the exosome 3'->5' exoribonuclease complex - also associated with the GTPase Ran - interacts directly with EXOSC1 Structure: belongs to the Rnase PH family Compartment: nucleus, nucleolus Expression: - expressed in testes Pathology: - highly expressed in a variety of hematopoietic & epithelial tumor cell lines, but not in normal hematopoietic tissues or other normal tissue, with the exception of testis

General

nuclear protein phosphoprotein protein subunit

Properties

SIZE: entity length = 235 aa MW = 25 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S20} Ser phosphorylation site {S27}

Database Correlations

OMIM 606492 UniProt Q9NQT4 PFAM correlations

References

UniProt :accession Q9NQT4