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evolutionary divergent human gene
Genetics:
- genes that have diverged from those of other primates since the origins of Homo sapiens.
- these genes, relatively few in number, perhaps a hundred or so, may play a role in the differential longevity & intelligence of humans compared with other primates.
Related
evolutionary divergent human protein
human longevity gene
Specific
AQP7 (aquaporin 7) gene
ARHGEF5 (rho guanine nucleotide exchange factor 5) gene (transforming immortalized mammary oncogene, TIM)
chrfam7a gene
CHRNA7 (nicotinic receptor alpha-7) gene
neuronal apoptosis inhibitory (NAIP) gene
PAK2 (p21-associated kinase 2) gene
ROCK1 (rho-associated coiled-coil-containing protein kinase) gene
SLC6A13 (Na+/Cl- dependent GABA transporter 2 ) gene
SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2) gene
USP10 (ubiquitin-specific protease-10) gene
USP14 (ubiquitin-specific protease-14) gene
General
gene
Properties
MOTIF: transcription factor binding site
transcriptional start site
exon
intron
transcriptional termination site
References
- Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L,
Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-
Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM.
Lineage-specific gene duplication and loss in human and great
ape evolution.
PLoS Biol. 2004 Jul;2(7):E207. Epub 2004 Jul 13.
PMID: 15252450
- Chimpanzee Sequencing and Analysis Consortium.
Initial sequence of the chimpanzee genome and comparison with
the human genome.
Nature. 2005 Sep 1;437(7055):69-87.
PMID: 16136131