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evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (protein SITPEC, ECSIT)
Function:
1) adapter protein of Toll-like & IL-1 receptor signaling pathway involved in the activation of NF-kappa-B via MAP3K1
2) promotes proteolytic activation of MAP3K1
3) involved in BMP signaling pathway
4) required for normal embryonic development
5) required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase
6) interacts with MAP3K1, SMAD4 & TRAF6
7) interacts with SMAD1 only after BMP4-treatment
8) interacts with NDUFAF1
Structure: belongs to the ECSIT family
Compartment: cytoplasm, nucleus, mitochondrion
Alternative splicing: named isoforms=2
General
mitochondrial protein
nuclear protein
Properties
SIZE: MW = 49 kD
entity length = 431 aa
COMPARTMENT: mitochondria
cytoplasm
cell nucleus
Database Correlations
OMIM 608388
UniProt Q9BQ95
Pfam PF06239
References
- UniProt :accession Q9BQ95
- Kopp et al. Genes & Dev 13:2059-71, 1999