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etropic viral integration site 1 protein homolog; evi-1 protein; MDS1 & EVI1 complex locus protein EVI1 (EVI-1, EVI1, MECOM)
Function:
- may interact with CTBP1 (putative)
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure: contains 10 C2H2-type Zn+2 fingers
Compartment: nucleus
Alternative splicing: named isoforms=2
Pathology:
- chromosomal translocation t(3;21)(q26;q22) involving EVI1 with RUNX1/AML1 is a cause of acute myelogenous leukemia (AML)
Related
evi-1 proto-oncogene
General
C2H2 type zinc finger protein
DNA-binding protein
phosphoprotein
proto oncogene protein
transcription factor (TF)
Properties
SIZE: entity length = 1051 aa
MW = 118 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 21-44
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 75-97
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 103-125
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 131-154
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 160-182
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 188-210
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 217-239
EFFECTOR-BOUND: Zn+2
nuclear translocation signal {421-434}
CTBP-binding motif 1 {553-557}
CTBP-binding motif 2 {584-588}
Zn finger C2H2-type
SITE: 733-755
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 761-784
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 790-812
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S854}
Ser phosphorylation site {S858}
Ser phosphorylation site {S860}
acidic region {886-937}
MOTIF: acidic residue (SEVERAL)
Database Correlations
OMIM 165215
UniProt Q03112
Pfam PF00096
References
- UniProt :accession Q03112
- Hunter T.
Cooperation between oncogenes.
Cell. 1991 Jan 25;64(2):249-70. Review.
PMID: 1988147
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/EVI103q26ID19.html