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protein EVI2B; ecotropic viral integration site 2B protein homolog; EVI-2B (EVI2B EVDB)
Compartment:
- membrane; single-pass type 1 membrane protein
Expression:
- bone marrow, peripheral blood mononuclear cells, fibroblasts & Epstein-Barr virus-transformed lymphoblastoid cell lines
Pathology:
- implicated in leukemogenesis
- may function as an oncogene in retrovirus-induced myeloid tumors
General
glycoprotein
membrane protein
phosphoprotein
proto oncogene protein
Properties
SIZE: entity length = 448 aa
MW = 49 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
MOTIF: N-glycosylation site {N16}
N-glycosylation site {N50}
N-glycosylation site {N114}
transmembrane domain {203-226}
Ser phosphorylation site {S268}
Ser phosphorylation site {S271}
Ser phosphorylation site {S278}
Ser phosphorylation site {S294}
Database Correlations
OMIM 158381
UniProt P34910
References
UniProt :accession P34910