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protein EVI2A; ecotropic viral integration site 2A protein homolog; EVI-2A (EVI2A, EVDA, EVI2)
Function:
- may complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor
Structure: belongs to the EVI2A family
Compartment: membrane; single-pass type 1 membrane protein
Pathology:
- implicated in leukemogenesis
- may function as an oncogene in retrovirus-induced myeloid tumors
General
glycoprotein
membrane protein
phosphoprotein
proto oncogene protein
Properties
SIZE: entity length = 232 aa
MW = 26 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-26}
N-glycosylation site {N27}
N-glycosylation site {N34}
N-glycosylation site {N45}
N-glycosylation site {N69}
N-glycosylation site {N108}
transmembrane domain {131-156}
Ser phosphorylation site {S207}
Database Correlations
OMIM 158380
UniProt P22794
Pfam PF05399
Entrez Gene 2123
Kegg hsa:2123
References
UniProt :accession P22794