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eukaryotic translation initiation factor 4E (eIF4E, mRNA cap-binding protein)
Function:
- binds to 5'cap in mRNA
- phosphorylation appears to essential for activity
- overexpression of eIF-4E results in cell transformation
Structure:
- multi-subunit complex, the composition of which varies with external & internal environmental conditions
- composed of at least eIF4A, eIF4E & eIF4G
Interactions
molecular events
Related
eukaryotic translation initiation factor 4E type 1B (EIF4E1B)
eukaryotic translation initiation factor 4E type 2 (eIF4E type 2, eIF-4E type 2, mRNA cap-binding protein type 3, eukaryotic translation initiation factor 4E-like 3, eukaryotic translation initiation factor 4E homologous protein, mRNA cap-binding protein 4EHP, eIF4E-like protein 4E-LP, EIF4E2, EIF4EL3)
eukaryotic translation initiation factor 4E type 3; eIF-4E type 3; eIF-4E3; eIF4E type 3; eIF4E-3 (EIF4E3)
nuclear mRNA cap-binding protein
protein synthesis
General
initiation factor
phosphoprotein
RNA-binding protein
Properties
SIZE: MW = 24 kD
COMPARTMENT: cytoplasm
CELL: most cell types*
ORGANISM: eukaryote*
MOTIF: RNA-binding motif
FOR-BINDING-OF: inverted GTP 5' cap structure
Database Correlations
OMIM 133440
UniProt P06730
Entrez Gene 1977
References
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 442
- Pause et al Nature 371:762 1994
Component-of
80S elongation complex