eukaryotic translation initiation factor 4A

Unwinds regions of RNA secondary structure that hinder scanning of ribosome for AUG start site.

Specific

eukaryotic translation initiation factor 4A1 (EIF4A1, DDX2A) eukaryotic translation initiation factor 4A2 (EIF4A2, DDX2B)

General

DNA-binding protein helicase (DNA unwinding protein, DNA untwisting protein) initiation factor RNA-binding protein

Properties

COMPARTMENT: cell nucleus MOTIF: DNA-binding motif active site MOTIF: P-loop FOR-BINDING-OF: adenosine triphosphate RNA-binding motif FOR-BINDING-OF: ribonucleic acid ATP-binding site NAME: ATP-binding site DEAD/H box NAME: DEAD/H box

References

- Proud CG. Translation. Turned on by insulin. Nature. 1994 Oct 27;371(6500):747-8. PMID: 7935831